Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.

نویسندگان

  • Hongjie Zhang
  • Katharina Rothwangl
  • Andrew D Mesecar
  • Ali Sabahi
  • Lijun Rong
  • Harry H S Fong
چکیده

Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC(50) 2.31 muM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

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عنوان ژورنال:
  • Journal of natural products

دوره 72 12  شماره 

صفحات  -

تاریخ انتشار 2009